T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis
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چکیده
منابع مشابه
T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis
Dysregulated T cell responses to enteric bacteria have been implicated as a common mechanism underlying pathogenesis in rodent models of colitis. However, the bacterial species and T cell specificities that induce disease have been poorly defined. We have developed a model system in which target antigen, bacterial host, and corresponding T cell specificity are defined. OVA-specific T cells from...
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Background: Synbiotics have been used in the prevention and treatment of various immunological diseases. We aimed to investigate the synergistic clinical and immunologic effects of synbiotics and subcutaneous allergen immunotherapy (SCIT) combination in patients with allergic rhinitis. Materials and Methods: Nineteen individuals with all...
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After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis o f T C R V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper ceils that expres...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2002
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2001889